Astroglial Activation and Tau Hyperphosphorylation Precede to Neuron Loss in a Neurodegenerative Mouse Model
نویسندگان
چکیده
منابع مشابه
Tau suppression in a neurodegenerative mouse model improves memory function.
Neurofibrillary tangles (NFTs) are the most common intraneuronal inclusion in the brains of patients with neurodegenerative diseases and have been implicated in mediating neuronal death and cognitive deficits. Here, we found that mice expressing a repressible human tau variant developed progressive age-related NFTs, neuronal loss, and behavioral impairments. After the suppression of transgenic ...
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ژورنال
عنوان ژورنال: CNS Neuroscience & Therapeutics
سال: 2016
ISSN: 1755-5930
DOI: 10.1111/cns.12509